:root {
  color-scheme: dark;
  --bg: #071016;
  --panel: #0c171e;
  --panel-2: #101f27;
  --line: #20323b;
  --muted: #89a0aa;
  --text: #ecf5f6;
  --cyan: #48e0cf;
  --lime: #c7f36b;
  --orange: #ff9e62;
  --blue: #58a6ff;
  --red: #ff6f70;
  --radius: 14px;
}
* { box-sizing: border-box; }
html { background: var(--bg); }
body { margin: 0; min-width: 320px; background: radial-gradient(circle at 75% -20%, #173844 0, transparent 35%), var(--bg); color: var(--text); font-family: Inter, "Noto Sans JP", "Hiragino Sans", system-ui, sans-serif; font-size: 16px; }
button, input, select { font: inherit; }
button { cursor: pointer; }
.topbar { height: 64px; padding: 0 26px; border-bottom: 1px solid var(--line); display: flex; align-items: center; justify-content: space-between; background: rgba(7,16,22,.88); backdrop-filter: blur(16px); position: sticky; top: 0; z-index: 10; }
.brand { display: flex; align-items: center; gap: 10px; font-weight: 750; letter-spacing: -.02em; }
.brand-mark { display: grid; place-items: center; width: 34px; height: 34px; border: 1px solid #33766f; border-radius: 9px; color: var(--cyan); font-size: .8rem; background: #102a2a; }
.brand em { font-style: normal; color: var(--muted); font-size: .68rem; font-weight: 600; letter-spacing: .12em; padding-left: 4px; }
.top-actions { display: flex; gap: 10px; }
.ghost-btn, .primary-btn { border-radius: 9px; padding: 9px 14px; border: 1px solid var(--line); color: var(--text); background: #101d24; font-size: .85rem; }
.primary-btn { background: var(--cyan); color: #06201d; border-color: var(--cyan); font-weight: 750; box-shadow: 0 5px 24px rgba(72,224,207,.16); }
.workspace { max-width: 1560px; margin: 0 auto; display: grid; grid-template-columns: 300px 1fr; min-height: calc(100vh - 64px); }
.controls-panel { border-right: 1px solid var(--line); padding: 25px 22px 36px; background: rgba(8,19,25,.82); }
.controls-panel section + section { border-top: 1px solid var(--line); margin-top: 25px; padding-top: 24px; }
.section-head, .card-head { display: flex; justify-content: space-between; align-items: flex-start; gap: 12px; }
h1, h2, p { margin-top: 0; }
h1 { font-size: 1.05rem; margin-bottom: 0; }
h2 { font-size: .98rem; margin-bottom: 0; letter-spacing: -.01em; }
.helper { color: var(--muted); font-size: .78rem; margin: 7px 0 20px; line-height: 1.5; }
.status { color: var(--cyan); font-size: .67rem; letter-spacing: .12em; border: 1px solid #25564f; border-radius: 99px; padding: 4px 7px; }
.status i { display: inline-block; width: 6px; height: 6px; background: var(--cyan); border-radius: 50%; margin-right: 4px; box-shadow: 0 0 8px var(--cyan); }
.control-list { display: grid; gap: 18px; }
.slider-row { display: grid; gap: 8px; }
.slider-row.compact { margin-top: 18px; }
.slider-meta { display: flex; justify-content: space-between; align-items: baseline; }
.slider-meta label { font-size: .82rem; font-weight: 650; }
.slider-meta label span { color: var(--muted); font-size: .68rem; font-weight: 500; margin-left: 5px; }
.slider-meta output { font-variant-numeric: tabular-nums; color: var(--cyan); font-size: .8rem; }
.slider-meta sub { font-size: .72em; }
.range-ends { display: flex; justify-content: space-between; color: #58717b; font-size: .62rem; margin-top: -3px; }
input[type="range"] { width: 100%; accent-color: var(--cyan); }
input[type="range"]::-webkit-slider-runnable-track { height: 4px; background: #24404a; border-radius: 4px; }
input[type="range"]::-webkit-slider-thumb { margin-top: -5px; }
.select-label { display: block; margin-top: 16px; margin-bottom: 7px; color: var(--muted); font-size: .75rem; }
select { width: 100%; background: #101e25; color: var(--text); border: 1px solid var(--line); border-radius: 8px; padding: 10px; }
.preset-grid { display: grid; grid-template-columns: 1fr 1fr; gap: 8px; margin-top: 14px; }
.preset { background: #101e25; color: var(--muted); border: 1px solid var(--line); padding: 9px 5px; border-radius: 8px; font-size: .76rem; }
.preset.active { border-color: #3a8078; color: var(--cyan); background: #102b2a; }
.results-panel { padding: 25px 28px 40px; min-width: 0; }
.pathway-card, .cell-card, .chart-card, .motor-card, .sensitivity-card { background: linear-gradient(145deg, rgba(17,33,41,.94), rgba(9,20,26,.96)); border: 1px solid var(--line); border-radius: var(--radius); padding: 20px; box-shadow: 0 16px 40px rgba(0,0,0,.12); }
.eyebrow { display: block; color: var(--muted); font-size: .62rem; letter-spacing: .18em; margin-bottom: 5px; }
.phenotype { color: var(--cyan); background: #102c2b; border: 1px solid #285e59; font-size: .72rem; padding: 6px 9px; border-radius: 99px; }
.pathway { display: grid; grid-template-columns: 1fr auto 1fr auto 1fr auto 1fr; align-items: center; gap: 10px; margin-top: 20px; }
.node { min-height: 108px; border: 1px solid var(--line); background: #0b181f; border-radius: 11px; padding: 13px; display: grid; grid-template-columns: 1fr auto; grid-template-rows: auto 1fr auto; gap: 4px; position: relative; overflow: hidden; }
.node::before { content: ""; position: absolute; inset: auto 0 0; height: 3px; background: var(--cyan); opacity: .8; }
.node small { grid-column: 1/-1; color: var(--muted); font-size: .59rem; letter-spacing: .14em; }
.node strong { align-self: center; font-size: .91rem; }
.node span { align-self: center; font-size: 1.35rem; font-weight: 760; font-variant-numeric: tabular-nums; color: var(--cyan); }
.node b { grid-column: 1/-1; color: var(--muted); font-weight: 500; font-size: .68rem; }
.node.response::before { background: var(--lime); }
.node.response span { color: var(--lime); }
.node.motor::before { background: var(--orange); }
.node.motor span { color: var(--orange); }
.arrow { color: #56717b; font-size: 1.35rem; text-align: center; }
.arrow span { display: block; color: var(--muted); font-size: .59rem; white-space: nowrap; margin-bottom: 2px; }
.metrics-grid { display: grid; grid-template-columns: repeat(4, 1fr); gap: 12px; margin: 14px 0; }
.metric { background: #0d1a21; border: 1px solid var(--line); border-radius: 11px; padding: 15px 16px; display: grid; grid-template-columns: 1fr auto; align-items: baseline; }
.metric > span { color: var(--muted); font-size: .72rem; }
.metric strong { grid-row: span 2; font-size: 1.35rem; font-variant-numeric: tabular-nums; }
.metric small { color: #58717b; font-size: .62rem; margin-top: 5px; }
.metric.accent strong { color: var(--orange); }
.cell-card { margin-bottom: 14px; overflow: hidden; }
.cell-head { align-items: center; }
.cell-readouts { display: flex; align-items: center; gap: 17px; color: var(--muted); font-size: .7rem; }
.cell-readouts span { white-space: nowrap; }
.cell-readouts strong { color: var(--text); font-size: .78rem; margin-left: 3px; font-variant-numeric: tabular-nums; }
.dot { display: inline-block; width: 7px; height: 7px; border-radius: 50%; margin-right: 5px; box-shadow: 0 0 8px currentColor; }
.ligand-dot { color: var(--blue); background: var(--blue); }.repellent-dot { color: var(--red); background: var(--red); }.yp-dot { color: var(--lime); background: var(--lime); }.motor-dot { color: var(--orange); background: var(--orange); }.bundle-dot { color: #e9f7b0; background: #e9f7b0; }
.cell-stage { height: 390px; margin: 14px -3px 0; border: 1px solid #19323b; border-radius: 12px; position: relative; overflow: hidden; background: radial-gradient(ellipse at 50% 47%, #14323b 0, #09171d 55%, #061015 100%); }
#cellScene { width: 100%; height: 100%; display: block; }
.scene-key { position: absolute; left: 13px; bottom: 12px; display: flex; gap: 14px; padding: 7px 10px; border-radius: 8px; color: #8fa3ab; background: rgba(5,14,18,.78); border: 1px solid #1c343c; font-size: .63rem; backdrop-filter: blur(8px); }
.scene-key i { display: inline-block; width: 7px; height: 7px; border-radius: 50%; margin-right: 5px; }
.key-receptor { background: #58a6ff; }.key-chea { background: #48e0cf; }.key-chey { background: #c7f36b; }.key-chez { background: #ff6f70; }.key-bundle { background: #e9f7b0; }
.playback { display: grid; grid-template-columns: 34px 48px 1fr 32px auto; gap: 10px; align-items: center; margin-top: 12px; color: var(--muted); font-size: .68rem; }
.playback output { color: var(--cyan); text-align: right; font-variant-numeric: tabular-nums; }
.playback input[type="range"] { accent-color: var(--lime); }
.playback label { white-space: nowrap; }
.playback label input { vertical-align: -2px; accent-color: var(--cyan); }
.play-button { width: 32px; height: 30px; border: 1px solid #31555d; border-radius: 7px; color: var(--cyan); background: #10242b; font-weight: 800; }
.analysis-grid { display: grid; grid-template-columns: minmax(0, 1.65fr) minmax(300px, .8fr); gap: 14px; }
.chart-head { align-items: center; }
.legend { display: flex; gap: 16px; color: var(--muted); font-size: .68rem; }
.legend span::before { content: ""; display: inline-block; width: 8px; height: 8px; border-radius: 50%; margin-right: 5px; }
.l-chey::before { background: var(--lime); }.l-cw::before { background: var(--orange); }.l-input::before { background: var(--blue); }
.canvas-wrap { height: 292px; margin-top: 12px; }
#signalChart { width: 100%; height: 100%; display: block; }
.behavior { font-size: .75rem; font-weight: 800; letter-spacing: .12em; padding: 6px 9px; border-radius: 7px; }
.behavior.run { color: var(--cyan); background: #10302d; }.behavior.tumble { color: var(--orange); background: #3b2218; }
.motor-array { display: flex; justify-content: center; gap: 13px; margin: 30px 0 24px; }
.motor-unit { text-align: center; color: var(--muted); font-size: .6rem; }
.motor-icon { width: 42px; height: 42px; border: 2px solid var(--cyan); border-radius: 50%; display: grid; place-items: center; margin-bottom: 7px; color: var(--cyan); font-size: 1.1rem; transition: .25s; }
.motor-unit.cw .motor-icon { border-color: var(--orange); color: var(--orange); background: rgba(255,158,98,.08); transform: rotate(55deg); }
.motor-summary { display: grid; grid-template-columns: auto 1fr auto; gap: 8px; align-items: center; font-size: .62rem; color: var(--muted); }
.bias-track { height: 5px; background: #18313a; border-radius: 4px; overflow: hidden; }
.bias-track i { display: block; height: 100%; background: linear-gradient(90deg,var(--cyan),var(--orange)); width: 20%; transition: width .3s; }
.motor-kinetics { display: flex; justify-content: space-between; gap: 12px; margin-top: 13px; padding-top: 11px; border-top: 1px solid #1b3038; color: var(--muted); font-size: .65rem; }
.motor-kinetics strong { color: var(--text); font-variant-numeric: tabular-nums; margin-left: 3px; }
.trajectory { width: 100%; height: 130px; display: block; margin-top: 18px; background: #08141a; border-radius: 9px; border: 1px solid #172a32; }
.sensitivity-card { margin-top: 14px; }
.sensitivity-card .card-head { align-items: end; }
.sensitivity-card .card-head > small { color: var(--muted); font-size: .67rem; }
.sensitivity-bars { display: grid; grid-template-columns: repeat(5, 1fr); gap: 14px; margin-top: 19px; }
.sens { display: grid; grid-template-columns: 38px 1fr 44px; align-items: center; gap: 8px; font-size: .72rem; }
.sens-track { height: 7px; background: #172a32; border-radius: 7px; overflow: hidden; position: relative; }
.sens-track i { display: block; height: 100%; border-radius: 7px; background: var(--cyan); }
.sens.negative .sens-track i { background: var(--orange); }
.sens output { text-align: right; color: var(--muted); font-variant-numeric: tabular-nums; }
.model-note { display: flex; gap: 14px; align-items: baseline; color: var(--muted); font-size: .7rem; line-height: 1.6; padding: 18px 4px 0; }
.model-note strong { color: #b9c8cd; white-space: nowrap; }
@media (max-width: 1050px) {
  .workspace { grid-template-columns: 250px 1fr; }
  .analysis-grid { grid-template-columns: 1fr; }
  .pathway { grid-template-columns: 1fr 24px 1fr; }
  .pathway .arrow:nth-of-type(2) { display: none; }
  .node.response { grid-column: 1; }.arrow:nth-of-type(3) { grid-column: 2; }.node.motor { grid-column: 3; }
  .sensitivity-bars { grid-template-columns: 1fr 1fr; }
  .cell-readouts { gap: 8px; flex-wrap: wrap; justify-content: flex-end; }
}
@media (max-width: 720px) {
  .topbar { padding: 0 14px; }.brand em, .ghost-btn { display: none; }
  .workspace { display: block; }.controls-panel { border-right: 0; border-bottom: 1px solid var(--line); }
  .results-panel { padding: 18px 14px 30px; }
  .metrics-grid { grid-template-columns: 1fr 1fr; }
  .pathway { grid-template-columns: 1fr 20px 1fr; }
  .arrow span { display: none; }.node { min-height: 98px; padding: 10px; }.node span { font-size: 1.1rem; }
  .legend { gap: 8px; }.chart-card, .motor-card, .pathway-card, .cell-card, .sensitivity-card { padding: 15px; }
  .cell-head { display: block; }.cell-readouts { justify-content: flex-start; margin-top: 12px; }.cell-stage { height: 310px; }.scene-key { gap: 8px; flex-wrap: wrap; }
  .playback { grid-template-columns: 34px 45px 1fr 28px; }.playback label { grid-column: 3 / -1; justify-self: end; }
  .sensitivity-bars { grid-template-columns: 1fr; }
  .motor-kinetics { display: grid; }
  .model-note { display: block; }.model-note strong { display: block; margin-bottom: 4px; }
}