:root{
  color-scheme:dark;--bg:#06131c;--panel:#0b1c27;--panel2:#0e2430;--line:#27404b;
  --text:#eef7f7;--muted:#94aeb5;--cyan:#49d6c7;--cyan2:#2aa99f;--amber:#ffb766;
  --red:#ff6f66;--ghost:#40515a;--blue:#72a7ff;--radius:18px;
  font-family:Inter,ui-sans-serif,-apple-system,BlinkMacSystemFont,"Segoe UI","Noto Sans JP",sans-serif
}
*{box-sizing:border-box}body{margin:0;background:radial-gradient(circle at 70% -20%,#123948 0,transparent 38%),var(--bg);color:var(--text);min-height:100vh}
button,input,select{font:inherit}.topbar{height:74px;border-bottom:1px solid var(--line);display:flex;align-items:center;justify-content:space-between;padding:0 28px;background:#071720df;backdrop-filter:blur(16px);position:sticky;top:0;z-index:10}
.brand{display:flex;align-items:center;gap:12px}.brand-mark{display:grid;place-items:center;width:38px;height:38px;border-radius:12px;background:linear-gradient(145deg,var(--cyan),#267b75);color:#03201f;font-size:24px;font-weight:900;box-shadow:0 0 24px #49d6c733}.brand div{display:flex;flex-direction:column}.brand strong{font-size:16px;letter-spacing:.02em}.brand span:last-child{font-size:12px;color:var(--muted);margin-top:2px}.method-button,.primary-button{border:1px solid var(--line);background:#102731;color:var(--text);border-radius:10px;padding:9px 14px;cursor:pointer}.method-button:hover,.primary-button:hover{border-color:var(--cyan)}
main{max-width:1600px;margin:auto;padding:22px 24px 48px}.species-strip{display:flex;align-items:center;justify-content:space-between;gap:16px;margin-bottom:16px}.species-tabs{display:flex;gap:8px;flex-wrap:wrap}.species-tab{border:1px solid var(--line);color:var(--muted);background:#091a24;padding:10px 14px;border-radius:12px;cursor:pointer;text-align:left;min-width:142px}.species-tab strong{display:block;color:inherit;font-size:14px}.species-tab small{font-size:11px}.species-tab.active{background:#123532;border-color:var(--cyan);color:var(--text);box-shadow:inset 0 0 0 1px #49d6c733}.strain-note{font-size:13px;color:var(--muted);text-align:right}
.workspace{display:grid;grid-template-columns:340px minmax(500px,1fr) 340px;gap:14px;align-items:stretch}.catalog-panel,.visual-panel,.detail-panel,.compare-section{background:linear-gradient(160deg,#0c202b,#081923);border:1px solid var(--line);border-radius:var(--radius);box-shadow:0 20px 50px #0004}.catalog-panel{height:748px;display:flex;flex-direction:column;padding:20px 16px;overflow:hidden}.catalog-head,.visual-head,.compare-head{display:flex;align-items:flex-start;justify-content:space-between;gap:12px}.catalog-head,.search-box,.filter-row{flex:0 0 auto}.eyebrow{font-size:11px;letter-spacing:.16em;color:var(--cyan);font-weight:800}.catalog-head h1,.visual-head h2,.compare-head h2{margin:5px 0 0;font-size:21px}.count{font-size:12px;color:var(--muted);background:#122b36;padding:5px 8px;border-radius:999px}.search-box{display:flex;align-items:center;gap:8px;border:1px solid var(--line);background:#071720;border-radius:11px;padding:0 11px;margin:17px 0 12px}.search-box:focus-within{border-color:var(--cyan)}.search-box input{width:100%;background:none;border:0;outline:0;color:var(--text);padding:12px 0;font-size:14px}.filter-row{display:flex;gap:6px;overflow-x:auto;overflow-y:hidden;min-height:43px;padding-bottom:11px}.filter-chip{white-space:nowrap;border:1px solid var(--line);background:transparent;color:var(--muted);border-radius:999px;padding:6px 10px;font-size:12px;cursor:pointer}.filter-chip.active{background:var(--cyan);border-color:var(--cyan);color:#04201e;font-weight:800}.protein-list{flex:1 1 auto;min-height:0;overflow-y:auto;overflow-x:hidden;padding-right:5px}.protein-card{width:100%;min-height:64px;border:1px solid transparent;background:transparent;color:var(--text);display:grid;grid-template-columns:58px 1fr auto;align-items:center;gap:12px;text-align:left;border-radius:13px;padding:11px 10px;cursor:pointer;margin-bottom:5px}.protein-card:hover{background:#112833}.protein-card.active{border-color:#3f8f89;background:linear-gradient(90deg,#143a38,#102b34)}.gene-badge{display:grid;place-items:center;min-height:40px;background:#17303b;border-radius:9px;font-family:ui-monospace,SFMono-Regular,Menlo,monospace;font-weight:800;color:var(--cyan);font-size:12px;padding:4px}.protein-card.active .gene-badge{background:var(--cyan);color:#05211f}.protein-name{font-size:14px;font-weight:650;line-height:1.4}.protein-stage{display:block;font-size:12px;color:var(--muted);margin-top:3px;line-height:1.35}.protein-arrow{color:#5f7880}
.visual-panel{height:748px;padding:18px;min-width:0}.visual-head{height:58px}.legend{display:flex;gap:12px;font-size:11px;color:var(--muted);flex-wrap:wrap;justify-content:flex-end}.legend span{display:flex;align-items:center;gap:5px}.dot{width:8px;height:8px;border-radius:50%;display:inline-block}.dot.built{background:var(--cyan)}.dot.affected{background:var(--red)}.dot.absent{background:var(--ghost)}.diagram-wrap{height:calc(100% - 58px);display:grid;grid-template-columns:minmax(0,1fr) 112px;gap:8px;background:radial-gradient(circle at 50% 55%,#173442 0,#081720 58%,#06131b 100%);border-radius:14px;border:1px solid #18323d;overflow:hidden}.diagram-wrap svg{width:100%;height:100%;overflow:visible}.stage-rail{border-left:1px solid #1d3843;padding:26px 10px;display:flex;flex-direction:column;justify-content:center;gap:5px}.stage-item{border-left:2px solid var(--ghost);padding:7px 0 7px 9px;font-size:11px;color:#718890;line-height:1.25}.stage-item.built{border-color:var(--cyan);color:#bfe9e4}.stage-item.affected{border-color:var(--red);color:#ffd0cb;font-weight:700}.stage-item.warn{border-color:var(--amber);color:#ffd9aa}.svg-label{font-size:12px;fill:#9db4ba}.component{transition:opacity .25s,filter .25s}.component.absent{opacity:.14;filter:saturate(.15)}.component.affected{filter:drop-shadow(0 0 7px #ff6f66);stroke:var(--red)!important}.component.warn{filter:drop-shadow(0 0 7px #ffb766);stroke:var(--amber)!important}.membrane-label{font-size:10px;fill:#718b94;letter-spacing:.1em}.molecular-surface{mix-blend-mode:screen}.rotor-spin{transform-box:fill-box;transform-origin:center;animation:rotor-ccw 1.25s linear infinite}.lipid-head{fill:#5da3af}.lipid-tail{stroke:#386572;stroke-width:2;stroke-linecap:round}.protein-highlight{fill:none;stroke:#dcffff;stroke-width:1.5;opacity:.5}@keyframes rotor-ccw{to{transform:rotate(-360deg)}}@media(prefers-reduced-motion:reduce){.rotor-spin{animation:none}}
.detail-panel{height:748px;padding:20px;overflow:auto}.detail-gene{font-family:ui-monospace,SFMono-Regular,Menlo,monospace;color:var(--cyan);font-size:30px;margin:5px 0 2px}.detail-name{font-size:13px;color:var(--muted);margin-bottom:18px}.endpoint-badge{border:1px solid #9d4a46;background:#3a2225;color:#ffc4bf;border-radius:10px;padding:10px 12px;font-weight:750;font-size:14px;margin:14px 0}.detail-panel h3{font-size:12px;color:#91aab1;letter-spacing:.09em;margin:20px 0 7px}.detail-panel p{font-size:14px;line-height:1.65;margin:0;color:#d8e6e8}.evidence{display:inline-flex;align-items:center;gap:6px;font-size:12px;color:#b9cbd0;border:1px solid var(--line);border-radius:999px;padding:5px 9px}.evidence i{width:7px;height:7px;border-radius:50%;background:var(--cyan)}.detail-source{display:block;color:#92cfc9;font-size:12px;line-height:1.45;margin:6px 0;text-decoration:none}.detail-source:hover{text-decoration:underline}.caution{border-left:2px solid var(--amber);padding-left:10px;color:#ffd4a3!important}.orthologs{display:flex;gap:6px;flex-wrap:wrap}.ortholog{font-family:ui-monospace,SFMono-Regular,Menlo,monospace;font-size:11px;background:#142c36;border:1px solid var(--line);border-radius:7px;padding:5px 7px;color:#bcd0d5}
.compare-section{margin-top:14px;padding:20px}.compare-head{align-items:end}.compare-control{display:flex;align-items:center;gap:9px;color:var(--muted);font-size:13px}.compare-control select{width:min(420px,52vw);background:#0a1c25;border:1px solid var(--line);color:var(--text);padding:10px 36px 10px 12px;border-radius:9px}.compare-grid{display:grid;grid-template-columns:repeat(4,1fr);gap:10px;margin-top:17px}.compare-card{background:#081923;border:1px solid #203b46;border-radius:12px;padding:14px}.compare-card.active-species{border-color:#3d817c}.compare-card h3{font-size:13px;margin:0 0 10px}.compare-card .compare-gene{font-family:ui-monospace,SFMono-Regular,Menlo,monospace;font-size:18px;color:var(--cyan)}.compare-card .mini-track{height:5px;background:#263943;border-radius:9px;margin:10px 0;overflow:hidden}.compare-card .mini-fill{height:100%;background:linear-gradient(90deg,var(--cyan2),var(--red));border-radius:9px}.compare-card p{font-size:12px;color:var(--muted);line-height:1.5;margin:0}.compare-missing{color:#60757d!important}
dialog{width:min(650px,calc(100% - 32px));border:1px solid var(--line);border-radius:18px;background:#0b202b;color:var(--text);padding:0;box-shadow:0 30px 90px #000b}dialog::backdrop{background:#001016c7;backdrop-filter:blur(5px)}.dialog-card{padding:26px;position:relative}.dialog-card h2{font-size:24px;margin:7px 0 14px}.dialog-card h3{font-size:14px;margin-top:22px}.dialog-card p,.dialog-card li{color:#c4d5d9;line-height:1.65;font-size:14px}.close-button{position:absolute;right:14px;top:12px;background:none;border:0;color:var(--muted);font-size:28px;cursor:pointer}.references{display:grid;gap:7px;margin-bottom:22px}.references a{color:#8ddbd2;text-decoration:none;font-size:13px}.references a:hover{text-decoration:underline}.primary-button{width:100%;background:var(--cyan);color:#03201e;border-color:var(--cyan);font-weight:800}
@media(max-width:1320px){.workspace{grid-template-columns:330px 1fr}.detail-panel{grid-column:1/-1;height:auto;min-height:300px;display:grid;grid-template-columns:1fr 1fr 1fr;gap:0 26px}.detail-main{grid-row:span 3}.compare-grid{grid-template-columns:repeat(2,1fr)}}
@media(max-width:760px){.topbar{padding:0 15px}.brand span:last-child{display:none}.method-button{font-size:12px;padding:8px}.species-strip{align-items:flex-start;flex-direction:column}.species-tabs{display:grid;grid-template-columns:1fr 1fr;width:100%}.species-tab{min-width:0}.strain-note{text-align:left}.workspace{display:block}.catalog-panel,.visual-panel,.detail-panel{height:auto;margin-bottom:12px}.catalog-panel{max-height:520px}.visual-panel{padding:14px}.visual-head{height:auto;display:block}.legend{justify-content:flex-start;margin:10px 0}.diagram-wrap{height:530px;grid-template-columns:1fr}.stage-rail{display:none}.detail-panel{display:block}.compare-head{display:block}.compare-control{margin-top:14px;align-items:flex-start;flex-direction:column}.compare-grid{grid-template-columns:1fr}main{padding:16px 12px 36px}}
:root{color-scheme:dark}
.phenotype-section>p{color:var(--muted);line-height:1.7;font-size:14px}.phenotype-controls{display:grid;grid-template-columns:repeat(5,minmax(0,1fr));gap:14px;margin:20px 0}.phenotype-controls label{display:flex;flex-direction:column;gap:9px;font-size:14px}.phenotype-controls select{width:100%;min-height:44px;background:#102632;color:#e6f5f4;border:1px solid #36535f;border-radius:8px;padding:10px;font:inherit}.phenotype-results{max-height:450px;overflow:auto;display:grid;gap:10px}.phenotype-results>p{font-size:14px;color:var(--muted)}.prediction-card{text-align:left;display:grid;grid-template-columns:minmax(120px,1fr) 2fr;gap:8px;padding:16px;border:1px solid #36535f;border-radius:10px;background:#102632;color:#e6f5f4;font:inherit;cursor:pointer}.prediction-card:hover,.prediction-card:focus-visible{border-color:#47d7c5}.prediction-card small{grid-column:1/-1;font-size:14px;line-height:1.5;color:#b4cbd1}.prediction-card span{font-size:14px}.uniprot-links{display:flex;flex-wrap:wrap;gap:8px 14px}.prediction-note{max-width:1000px}@media(max-width:900px){.phenotype-controls{grid-template-columns:repeat(2,minmax(0,1fr))}}@media(max-width:520px){.phenotype-controls,.prediction-card{grid-template-columns:1fr}.prediction-card span{grid-column:1}}
.topbar{flex-wrap:wrap;gap:12px}.brand{flex:1}.wt-grid{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:20px}.wt-grid article{min-width:0;background:#0b202a;border:1px solid #36535f;border-radius:12px;padding:14px}.wt-grid svg{display:block;width:100%;height:auto}.wt-grid h3{font-size:17px}.wt-grid .stage-rail{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));width:auto}.table-scroll,.evidence-scroll{overflow-x:auto}table{width:100%;border-collapse:collapse;font-size:14px;margin:12px 0}th,td{text-align:left;padding:9px;border-bottom:1px solid #36535f;vertical-align:top}.difference td:last-child{color:#ffbf73}.table-scroll p,.evidence-audit p,#nextObservations p{font-size:14px;line-height:1.7;color:#b4cbd1}.evidence-audit small{display:block;color:#a0b6bf;font-size:12px}.next-card{border:1px solid #36535f;background:#102632;border-radius:10px;padding:16px;margin:12px 0}.next-card h3{margin:0}.next-card button{font:inherit;font-size:14px;background:#183c49;color:#dbf7f3;border:1px solid #3a6a73;border-radius:7px;padding:9px 13px;margin:6px 8px 8px 0;cursor:pointer}.next-card details{font-size:14px;color:#b4cbd1}.next-card summary{cursor:pointer}.detail-panel{min-width:0}.detail-panel .evidence-audit{max-width:100%}@media(max-width:760px){.wt-grid{grid-template-columns:1fr}}
.topbar{height:auto;min-height:78px;padding-top:12px;padding-bottom:12px}.evidence-audit h3{font-size:14px}.evidence-audit .detail-source{font-size:14px}@media(max-width:1320px){.detail-panel .evidence-audit{grid-column:1/-1}}
.review-notice{border:1px solid #385d66;border-radius:12px;padding:14px 18px;margin-bottom:16px;background:#102630;color:#c1d6dc;font-size:14px;line-height:1.6}.review-notice p{margin:6px 0}.review-notice summary{cursor:pointer;color:var(--cyan)}.dot.warn{background:var(--amber)}button:focus-visible,select:focus-visible,input:focus-visible,summary:focus-visible{outline:2px solid var(--cyan);outline-offset:3px}
.visual-panel{display:flex;flex-direction:column}.visual-head{height:auto;flex:0 0 auto;min-height:58px;margin-bottom:8px}.diagram-wrap{height:auto;flex:1 1 auto;min-height:0}.legend{font-size:12px}.review-notice{flex-shrink:0}@media(max-width:760px){.diagram-wrap{height:530px;flex:none}.visual-head{min-height:0}}
.component.absent,.component.deleted,.component.affected{opacity:.55;filter:none!important}.component.absent :is(path,ellipse,circle,line,rect),.component.deleted :is(path,ellipse,circle,line,rect),.component.affected :is(path,ellipse,circle,line,rect),path.component.absent{fill:none!important;stroke:#738d99!important;stroke-width:1.6!important;stroke-dasharray:5 5!important;filter:none!important}.component.deleted :is(path,ellipse,circle,line,rect),.component.affected :is(path,ellipse,circle,line,rect){stroke:#ff9a92!important}.component.deleted{opacity:.8}
.readme-link{display:inline-flex;align-items:center;text-decoration:none;white-space:nowrap}.readme-link:hover{text-decoration:underline}.readme-link:focus-visible{outline:2px solid var(--cyan);outline-offset:3px}
.brand .version-badge{display:inline-block;margin:0 0 0 5px;padding:1px 6px;border:1px solid #3d756f;border-radius:5px;color:#a9efe3;font-size:11px;font-weight:650;letter-spacing:.02em;vertical-align:middle}